Protein atf4

Author: yslh

August undefined, 2024

Webb16 juli 2024 · ATF4 belongs to the basic-region leucine zipper (bZIP) family of transcription factors and functions as heterodimers with other bZIP proteins, such as c-Fos, c-Jun, or CCAAT/enhancer-binding... WebbExpression of ATF4 in cancer - Summary - The Human Protein Atlas ATF4 PATHOLOGY CANCER ANTIBODIES AND VALIDATION Dictionary Human pathology PROGNOSTIC …

Regulation of the unfolded protein response through ATF4 and

WebbATF4 regulates the expression of genes involved in oxidative stress, amino acid synthesis, differentiation, metastasis and angiogenesis. Transgenic studies have demonstrated … WebbATF4 activating transcription factor 4 ATP adenosine triphosphate C3 complement 3 CHOP C/EBP homologous protein CT computed tomography ER endoplasmic reticulum ERK1/2 extracellular signal-regulated kinases GSH glutathione HGF hepatocyte growth factor HO-1 heme oxygenase 1 HSP70 heat shock protein 70 I/R ischemia-reperfusion IL-6 … tea kettle old man

Translational Activation of ATF4 through Mitochondrial …

Webbför 2 dagar sedan · This suggested that ATF4 protected against liver cancer in some way. Further experiments led by postdoctoral fellow Feng He, PhD, confirmed that ATF4 promoted the expression of SLC7A11, a protein ... WebbATF4. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. WebbSearch: ATF4 - The Human Protein Atlas More information. Don't show this again. SECTIONS TISSUE BRAIN SINGLE CELL TYPE TISSUE CELL TYPE PATHOLOGY DISEASE … ej mortgage\u0027s

ATF4 plays a pivotal role in the development of functional ...

Webbför 8 timmar sedan · They found that Aβ42 caused 2 proteins — ATF4 and CREB3L2 — to bind together. The pairing of these 2 proteins is linked to about half of the gene expression changes that happen in brain cells ... WebbMitochondrial stress stimulates OMA1-dependent cleavage of DELE1 and leads to the accumulation of DELE1 in the cytosol, where it interacts with HRI and activates the eIF2α kinase activity of HRI. In addition, DELE1 is required for ATF4 translation downstream of eIF2α phosphorylation. Blockade of the OMA1-DELE1-HRI pathway triggers an ... tea kettle odorWebb16 jan. 2012 · In wild-type cells these oncogenes induced expression of the murine Atf4 gene along with the cyclin-dependent kinase inhibitor Cdkn2a, which encodes the cell senescence-associated proteins p16INK4 and p19ARF. Elevated levels of ATF4 were sufficient to suppress expression of these proteins and drive oncogenic transformation. ej navigator\\u0027s

"Webb30 aug. 2013 · We determined the effect of ATF4 on hepatic lipid metabolism in Atf4 (-/-) mice fed regular chow or provided with free access to fructose drinking water. ATF4 … " - Protein atf4

Protein atf4

The mTORC1-mediated activation of ATF4 promotes …

Webb1 jan. 2024 · The ATF4 mRNA contains a 5′-UTR (untranslated region) region with various regulatory elements responsive to translational control ( 21) by eukaryotic translation initiation factor 2A (EIF2A). Without stress, EIF2A is not phosphorylated and ATF4 translation is low; under stress, EIF2A is phosphorylated on Ser51 and ATF4 translation … WebbProduktinformationen "ATF4 Recombinant Protein" Source : Escherichia Coli. ATF4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 510 amino acids (1-351 a.a.) and having a molecular mass of 56.6kDa.ATF4 is fused to a 159 amino acid His-Calmodulin-tag at N-terminus & purified by proprietary …

Did you know?

WebbSubcellular - ATF4 - The Human Protein Atlas SUMMARY TISSUE BRAIN SINGLE CELL TISSUE CELL PATHOLOGY DISEASE IMMUNE BLOOD SUBCELL CELL LINE ATF4 … Webb21 mars 2024 · ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. Diseases associated with ATF4 include Coffin-Lowry Syndrome and Fatty Liver Disease . …

Webb25 juni 2013 · ATF4 is a master regulator that plays a crucial role in the adaptation to stresses by regulating the transcription of many genes ( 3 , 10–12 ). ATF4 triggers increased transcription by binding to C/EBP-ATF Response Element (CARE) sequences of a subset of specific target genes ( 13–15 ). WebbATF4. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. …

WebbATF4 and FAM129A protein expression is increased in patient PCa samples compared with benign prostate. Importantly, in vivo therapeutic silencing of ATF4-FAM129A axis … WebbATF4 is a basic leucine zipper (bZIP) stress-responsive transcription factor that belongs to the CREB/ATF family of transcription factors that are able to homodimerize or heterodimerize to regulate gene expression (Rzymski et al., 2009; Wortel et al., 2024 ).

Webb4 apr. 2024 · Title: Activating transcription factor 4 regulates hypoxia inducible factor 1α in chronic hypoxia in pancreatic cancer cells. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Title: ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Cooperation of ATF4 and CTCF promotes adipogenesis through …

Webb5 nov. 2024 · Expression of ATF4 in TM promotes aberrant protein synthesis and ER client protein load, leading to TM dysfunction and cell death. These events lead to IOP elevation and glaucomatous... tea kettle night lightWebbTXLNG overexpression had no effect on ATF4 protein levels, while ATF4 overexpression increased ATF4 protein levels. Furthermore, ATF4 overexpression notably abolished the improvements in IR adipocyte dysfunction caused by TXLNG overexpression. In conclusion, TXLNG improves IR in obese subjects in vitro and in vivo by inhibiting ATF4 ... ej navigator\u0027sWebb25 jan. 2024 · Next, as ROS generated by PC induced ER stress, we found that TUDCA reduced ER stress-associated proteins (78 kDa glucose-regulated protein (GRP78), protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2α), activating transcription factor 4 (ATF4), inositol-requiring protein 1 alpha (IRE1 … ej mostovi na moraci tekstWebbThe ATF4 transcription factor has the ability to form dimers with many different proteins that influence gene expression and cell fate. ATF4 binds to C/EBP‐ATF response element (CARE) sequences which work together to increase the transcription of … ej nazi\u0027sWebbThe antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays through … tea kettle omahaWebb19 mars 2024 · ATF4 generates several additional adaptations to amino acid insufficiency, including further inhibition of global protein synthesis. Importantly, the mechanisms by … ej neutrino\\u0027sWebb1 mars 2024 · The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, … tea kettle old