Hif bnip3
WebBackground: To explore the roles of HIF1α- and HIF2α-regulated BNIP3 in hypoxia-induced injury of neurons. Methods: The sera of neonates with hypoxic-ischemic encephalopathy … Web27 de dez. de 2024 · HIF-1 α exerts its antiapoptotic function through transcriptional activation of antiapoptotic proteins: Bcl-2, apoptosis inhibitor (IAP-2), and GLUT1. On the other hand, a functional pathway of HIF-1 α can activate proapoptotic proteins: p53, Bax, and BNIP3 [ 5 ].
Hif bnip3
Did you know?
Web摘要:目的 探讨乙酸钠(NaAc)对氧糖剥夺(OGD)损伤后皮质神经元的作用及低氧诱导因子-1α(HIF-1α)表达的影响。方法 将OGD处理的皮质神经元作为脑缺血模型,采用细胞存活实验(CCK-8)、乳酸脱氢酶(LDH)释放实验检测NaAc处理后的神经元存活情况,Western blot方法检测OGD损伤后、NaAc处理后神经元中HIF-1α蛋白 ... Web13 de jul. de 2024 · Hypoxia-inducible factor-1 (HIF-1) dependent expressions of DRP1 and phosphorylated DRP1 and mitophagy-related protein BNIP3 were significantly upregulated in hypoxia-surviving HCC cells (Fig. 1e).
WebAnti-HIF-1 alpha antibody [EP1215Y] (ab51608) View more associated products. Overview. Product name. HIF1a + BNIP3 Hypoxia Response Human Flow Cytometry Kit. Detection method. ... BNIP3 readout. HeLa … WebUnder normoxia, HIF-1 alpha undergoes hydroxylation at specific prolyl residues which leads to an immediate ubiquitination and subsequent proteasomal degradation of the subunit. In contrast, under hypoxia, HIF …
Web9 de abr. de 2024 · Nanomaterials are gaining increasing attention as innovative materials in medicine. Among nanomaterials, zinc oxide (ZnO) nanostructures are particularly appealing because of their opto-electrical, antimicrobial, and photochemical properties. Although ZnO is recognized as a safe material and the Zn ion (Zn2+) concentration is strictly regulated … WebThese results provided not only mechanistic insights into the neurotoxicity of ZIF-67, i.e., ROS-induced apoptosis through activating the HIF-1α/BNIP3 signaling pathway, but also …
Web2 de set. de 2024 · 3.3. HIF-1α/BNIP3 Pathway Was Activated during Luteolysis. Previous studies have revealed that hypoxia is involved in the apoptosis of luteal cells in vitro [], implying that HIF-1α may participate in apoptosis during luteal regression in vivo.Thus, we detected the expression changes of HIF-1α signaling and then found an obvious …
Webhif-1蛋白水平的高低决定于细胞所处环境的氧含量。生理状态下,hif-1α蛋白水平极低[4]。但在低氧状态下,由于羟化过程受到抑制,hif-1α无法降解,hif-1α快速积累于胞质内,通过募集其他相关辅助蛋白形成复合体后,hif-1α最终转入细胞核,与靶基因dna ... order custom sized printsWeb缺氧诱导因子及相关靶基因与卒中的关系研究进展.pdf order custom sofa slipcoversWeb21 de mar. de 2024 · BNIP3 (BCL2 Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include Hereditary Leiomyomatosis And Renal Cell … irctc captcha not loadingWeb6 de out. de 2024 · HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In immunity, infected and inflamed tissues are often hypoxic, and HIF helps immune cells adapt. irctc card chargesWeb15 de set. de 2001 · Bcl2/adenovirus EIB 19kD-interacting protein 3 (BNIP3) ... HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in … irctc cancellation feeWeb1 de set. de 2024 · HIF-1α-BNIP3 signaling pathway contributes to mitophagosome formation in renal tubular cells in confocal assay. Representative immunofluorescence … irctc card benefitsWeb通过对这3个物种的 phd2 的功能进行探究发现: 3个物种的 phd2 在常氧情况下均可以降解3个物种的 hif-α(包括hif-1α和hif-2α) 蛋白, 而在低氧(o 2 浓度小于2%)情况下, phd2 则无法明显降解 hif-α 蛋白。在常氧下, 鲸类的 phd2 降解 hif-α 是依赖于识别鲸类的 hif-1α 上ltllap和 ... irctc cancellation policy 2021