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WebFeb 9, 2024 · Pharmacology Mechanism of Action. Guanfacine is a selective alpha 2A-adrenoreceptor agonist that reduces sympathetic nerve impulses, resulting in reduced sympathetic outflow and a subsequent decrease in vasomotor tone and heart rate.In addition, guanfacine preferentially binds postsynaptic alpha 2A-adrenoreceptors in the … WebJun 22, 2024 · He has been taking 1mg at night and .5mg in the mornings. He is also on Ritalin. The reason we started guanfacine was to hopefully cover the areas of time where stimulant has worn off (morning and early evening) as well as to help some with impulsivity/emotional deregulation. WebJun 19, 2015 · The study spanned over a period of 9 weeks, and participants received either Guanfacine XR in doses of 1 mg, 2 mg, 3 mg, or 4 mg – or a placebo. ... This review … hertz asheboro